Sirt6^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Sirt6^tm1Fwa
• Name: sirtuin 6; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:3686893
• Synonyms: SIRT6KO
• Gene: Sirt6 Location: Chr10:81457621-81463631 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Sirt6^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112817
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ gene was inserted in frame after the first 21 bp of exon 1 via homologous recombination replacing exons 1 to 6. (J:112817)

Disease models

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirt6 Mutation: 41 strains or lines available

References

• Original: J:112817 Mostoslavsky R, et al., Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006 Jan 27;124(2):315-29
• All: 28 reference(s)