Slc12a5^tm1Dlp
Targeted Allele Detail

Summary

• Symbol: Slc12a5^tm1Dlp
• Name: solute carrier family 12, member 5; targeted mutation 1, Eric Delpire
• MGI ID: MGI:3686895
• Synonyms: KCC2^-, KCC2b^-
• Gene: Slc12a5 Location: Chr2:164802766-164841651 bp, + strand Genetic Position: Chr2, 85.28 cM, cytoband G2-G3
• Alliance: Slc12a5^tm1Dlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113307
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A large portion of exon 1 was replaced with a PGK-neo cassette. Western blot analysis indicated a greater than 95% reduction in protein expression suggesting that this allele is a severe hypomorph. (J:113307)

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a5 Mutation: 45 strains or lines available

Notes

ES cell line = LT-1.

References

• Original: J:113307 Woo NS, et al., Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus. 2002;12(2):258-68
• All: 14 reference(s)