Vav1^tm3Tyb
Targeted Allele Detail

Summary

• Symbol: Vav1^tm3Tyb
• Name: vav 1 oncogene; targeted mutation 3, Victor L J Tybulewicz
• MGI ID: MGI:3686975
• Synonyms: Vav1^loxP
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^tm3Tyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113270
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A floxed neo was inserted into intron 9. Subsequent breeding resulted in the loss of the neo by cre mediated excision, leaving only a loxP site. (J:113270)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 60 strains or lines available

References

• Original: J:113270 Prisco A, et al., Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells. Immunity. 2005 Sep;23(3):263-74
• All: 1 reference(s)