Zfp36l1^tm1Seb
Targeted Allele Detail

Summary

• Symbol: Zfp36l1^tm1Seb
• Name: zinc finger protein 36, C3H type-like 1; targeted mutation 1, Sarah E Bell
• MGI ID: MGI:3686982
• Synonyms: Zfp36l1^-
• Gene: Zfp36l1 Location: Chr12:80154534-80159787 bp, - strand Genetic Position: Chr12, 36.46 cM
• Alliance: Zfp36l1^tm1Seb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113396
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced part of the coding sequence in exon 2, including sequences encoding the first zinc finger. The reading frame was disrupted by the insertion of the neo. RT-PCR confirmed the absence of transcript in mutant embryos. (J:113396)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp36l1 Mutation: 10 strains or lines available

References

• Original: J:113396 Bell SE, et al., The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn. 2006 Nov;235(11):3144-55
• All: 1 reference(s)