Cd79a^tm6Cgn
Targeted Allele Detail

Summary

• Symbol: Cd79a^tm6Cgn
• Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 6, University of Cologne
• MGI ID: MGI:3687009
• Synonyms: Igalpha^Y204F
• Gene: Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
• Alliance: Cd79a^tm6Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113407
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to allow for cre mediated replacement of exons 4 and 5, including the Y204F mutation. (J:113407)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79a Mutation: 24 strains or lines available

References

• Original: J:113407 Patterson HC, et al., The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. Immunity. 2006 Jul;25(1):55-65
• All: 1 reference(s)