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Tg(HLA-DQA1,HLA-DQB1)73Myl
Transgene Detail
Summary
Symbol: Tg(HLA-DQA1,HLA-DQB1)73Myl
Name: transgene insertion 73, Myra A Lipes
MGI ID: MGI:3687023
Synonyms: HLA-DQ8, HLA-DQ8 line 73
Transgene: Tg(HLA-DQA1,HLA-DQB1)73Myl  Location: unknown  
Alliance: Tg(HLA-DQA1,HLA-DQB1)73Myl page
Transgene
origin
Strain of Origin:  B6.129S2-H2-Ab1b-tm1Gru
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(HLA-DQA1,HLA-DQB1)73Myl expresses 2 genes
 
Mutation detailsThe 13.4 kb DQA1*301 and 19.9 kb DQB1*302 genes were subcloned into the pWE15 cosmid. The 33.3 kb fragment was purified and injected into fertilized eggs from H2Ab1tm1Gru on the C57BL/6 background. (J:88055)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Three separate lines were generated: 70, 73, and 275. Lines 73 and 275 differed primarily in severity of phenotype, with 73 being more severe than 275.
References
Original:  J:88055 Taylor JA, et al., A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol. 2004 Feb 15;172(4):2651-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory