Tg(TcraBDC12-4.1)10Jos
Transgene Detail

Summary

• Symbol: Tg(TcraBDC12-4.1)10Jos
• Name: transgene insertion 10, Joslin Diabetes Center
• MGI ID: MGI:3687036
• Synonyms: alpha10, BDC12.4 TCR alpha10
• Transgene: Tg(TcraBDC12-4.1)10Jos Location: unknown
• Alliance: Tg(TcraBDC12-4.1)10Jos page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraBDC12-4.1)10Jos expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)

• Mutation details: The TCR alpha (TRAV5D-4*04/TRAJ53*01) chain from the BDC12-4.1 clone was subcloned into a TCR cassette. (J:111874)
• Inheritance: Dominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:111874 Jasinski JM, et al., Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes. 2006 Jul;55(7):1978-84
• All: 3 reference(s)