Cxcr2^{tm1(IL8RB)Dktr}
Targeted Allele Detail

Summary

• Symbol: Cxcr2^{tm1(IL8RB)Dktr}
• Name: C-X-C motif chemokine receptor 2; targeted mutation 1, Wim Dokter
• MGI ID: MGI:3687177
• Synonyms: hCXCR2^-
• Gene: Cxcr2 Location: Chr1:74193153-74200405 bp, + strand Genetic Position: Chr1, 38.41 cM
• Alliance: Cxcr2^{tm1(IL8RB)Dktr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113489
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• The endogenous exon 1 was functionally replaced by the human coding sequence. (J:113489)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcr2 Mutation: 30 strains or lines available

References

• Original: J:113489 Mihara K, et al., Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. Eur J Immunol. 2005 Sep;35(9):2573-82
• All: 2 reference(s)