Hprt1^{tm1(CUX1)Anep}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CUX1)Anep}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Alain Nepveu
• MGI ID: MGI:3687214
• Synonyms: Hprt1^{tm1(Cutl1)Anep}
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CUX1)Anep} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113393
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(CUX1)Anep} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CUX1 (1523)

  Cux1	(MGI:88568)

• Mutation details: Human CUTL1 (CUX1) p75 cDNA was inserted under the control of the MMTV promoter and placed into the Hprt locus. Two lines were created: 48 and 50. (J:113393)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:113393 Cadieux C, et al., Transgenic Mice Expressing the p75 CCAAT-Displacement Protein/Cut Homeobox Isoform Develop a Myeloproliferative Disease-Like Myeloid Leukemia. Cancer Res. 2006 Oct 1;66(19):9492-501
• All: 3 reference(s)