Dgka^tm1Xpz
Targeted Allele Detail

Summary

• Symbol: Dgka^tm1Xpz
• Name: diacylglycerol kinase, alpha; targeted mutation 1, Xiaoping Zhong
• MGI ID: MGI:3687309
• Synonyms: Dgka^-, Dgka^tm1Gak
• Gene: Dgka Location: Chr10:128556003-128580724 bp, - strand Genetic Position: Chr10, 77.14 cM
• Alliance: Dgka^tm1Xpz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113564
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region encoding part of the C1B domain and the kinase domain, including the ATG, was replaced with a neomycin resistance cassette. (J:113564)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dgka Mutation: 87 strains or lines available

References

• Original: J:113564 Olenchock BA, et al., Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. Nat Immunol. 2006 Nov;7(11):1174-81
• All: 21 reference(s)