Rhoh^tm1Daw
Targeted Allele Detail

Summary

• Symbol: Rhoh^tm1Daw
• Name: ras homolog family member H; targeted mutation 1, David A Williams
• MGI ID: MGI:3687310
• Synonyms: Rhoh^-
• Gene: Rhoh Location: Chr5:66018556-66054043 bp, + strand Genetic Position: Chr5, 33.8 cM, cytoband D
• Alliance: Rhoh^tm1Daw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113565
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire coding region, located in exon 3. Absence of protein was confirmed by immunoblot analysis. (J:113565)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhoh Mutation: 13 strains or lines available

References

• Original: J:113565 Gu Y, et al., RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. Nat Immunol. 2006 Nov;7(11):1182-1190
• All: 7 reference(s)