Ucp2^{Gt(S20-3G1)Sor}
Gene trapped Allele Detail

Summary

• Symbol: Ucp2^{Gt(S20-3G1)Sor}
• Name: uncoupling protein 2 (mitochondrial, proton carrier); gene trap S20-3G1, Philippe Soriano
• MGI ID: MGI:3687318
• Synonyms: Ucp2^{Gt(FHCRC-GT-S20-3G1)Sor}
• Gene: Ucp2 Location: Chr7:100142565-100148832 bp, + strand Genetic Position: Chr7, 54.36 cM
• Alliance: Ucp2^{Gt(S20-3G1)Sor} page

Mutation origin

• Mutant Cell Line: S20-3G1
• Germline Transmission: Earliest citation of germline transmission: J:113539
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSAFARY
• Mutation details: A gene trap vector containing both Betagal and a neomycin cassette inserted into the locus. Northern blot confirmed absence of transcript in mutant mice. Western blot failed to detect protein in mutant spleen samples. (J:113539)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-S20-3G1	CL706119 ; (MGI Seq Detail)	3' RACE	Chr7:100145933-100147425 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  37 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucp2 Mutation: 41 strains or lines available

References

• Original: J:113539 Horvath B, et al., Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochem Pharmacol. 2002 Aug 1;64(3):369-74
• All: 4 reference(s)