Trp53^tm3Xu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm3Xu
• Name: transformation related protein 53; targeted mutation 3, Yang Xu
• MGI ID: MGI:3687352
• Synonyms: p53^K317R
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm3Xu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112302
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Single point mutation
• Mutation details: Lysine codon 317 (AAA) in exon 9 was changed to arginine (AGA) (p.K317R). The LoxP site flanked neomycin resistance gene cassette that was inserted into intron 4 was removed via Cre-mediated recombination. This mutation prevents acetylation of the residue in the encoded peptide. (J:112302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 239 strains or lines available

References

• Original: J:112302 Chao C, et al., Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol. 2006 Sep;26(18):6859-69
• All: 1 reference(s)