Rr159^tm1.1Fwa
Targeted Allele Detail

Summary

• Symbol: Rr159^tm1.1Fwa
• Name: regulatory region 159; targeted mutation 1.1, Frederick W Alt
• MGI ID: MGI:3687498
• Synonyms: 3'Ekappa^delta, Igk-Eik^tm1.1Fwa, Igk^tm1.1Fwa
• Gene: Rr159 Location: Chr6:70712244-70713044 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr159^tm1.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113715
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP site flanked neomycin resistance gene cassette in place of the entire 808 bp 3' enhancer region (3'Ekappa), downstream of the Igk cluster, was removed via cre-mediated recombination. (J:113715)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr159 Mutation: 0 strains or lines available

References

• Original: J:113715 Gorman JR, et al., The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. Immunity. 1996 Sep;5(3):241-52
• All: 6 reference(s)