Nlgn1^tm1Bros
Targeted Allele Detail

Summary

• Symbol: Nlgn1^tm1Bros
• Name: neuroligin 1; targeted mutation 1, Nils Brose
• MGI ID: MGI:3687638
• Synonyms: NLGN1 KO
• Gene: Nlgn1 Location: Chr3:25480379-26386609 bp, - strand Genetic Position: Chr3, 10.38 cM, cytoband A3
• Alliance: Nlgn1^tm1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113647
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the exon encompassing the translational start site at 546 bp. Western blot confirmed absence of full length and truncated protein in these mutants. (J:113647)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn1 Mutation: 66 strains or lines available

References

• Original: J:113647 Varoqueaux F, et al., Neuroligins determine synapse maturation and function. Neuron. 2006 Sep 21;51(6):741-54
• All: 28 reference(s)