Nlgn2^tm1Bros
Targeted Allele Detail

Summary

• Symbol: Nlgn2^tm1Bros
• Name: neuroligin 2; targeted mutation 1, Nils Brose
• MGI ID: MGI:3687639
• Synonyms: NL2^-
• Gene: Nlgn2 Location: Chr11:69713949-69728610 bp, - strand Genetic Position: Chr11, 42.89 cM
• Alliance: Nlgn2^tm1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113647
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 380 bp fragment including the translation start site was replaced with a neo cassette via homologous recombination. Western blot confirmed absence of full length and truncated protein in whole brain homogenates from homozygous mice. (J:113647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn2 Mutation: 35 strains or lines available

References

• Original: J:113647 Varoqueaux F, et al., Neuroligins determine synapse maturation and function. Neuron. 2006 Sep 21;51(6):741-54
• All: 27 reference(s)