Pth1r^tm1Abas
Targeted Allele Detail

Summary

• Symbol: Pth1r^tm1Abas
• Name: parathyroid hormone 1 receptor; targeted mutation 1, Abdul B Abou-Samra
• MGI ID: MGI:3687642
• Gene: Pth1r Location: Chr9:110551153-110576213 bp, - strand Genetic Position: Chr9, 60.56 cM, cytoband F
• Alliance: Pth1r^tm1Abas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113660
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: A vector containing 7 serine to alanine mutations and a floxed neo-tk was inserted into the locus. The neo was subsequently removed via cre mediated recombination. (J:113660)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pth1r Mutation: 29 strains or lines available

References

• Original: J:113660 Bounoutas GS, et al., Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology. 2006 Oct;147(10):4674-9
• All: 3 reference(s)