Gata1^Plt13
Chemically induced Allele Detail

Summary

• Symbol: Gata1^Plt13
• Name: GATA binding protein 1; Plt13
• MGI ID: MGI:3687875
• Gene: Gata1 Location: ChrX:7825504-7842844 bp, - strand Genetic Position: ChrX, 3.59 cM, cytoband A2
• Alliance: Gata1^Plt13 page

Gata1^Plt13/Gata1⁺ mice exhibit megakaryocytosis and abnormal megakaryocyte maturation.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion in exon 2 disrupts the translation initiation codon. Wild-type protein was not detected in mutants. (J:113720)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata1 Mutation: 45 strains or lines available

References

• Original: J:113720 Majewski IJ, et al., A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14146-51
• All: 2 reference(s)