Pdcd1lg2^tm1Shr
Targeted Allele Detail

Summary

• Symbol: Pdcd1lg2^tm1Shr
• Name: programmed cell death 1 ligand 2; targeted mutation 1, Arlene H Sharpe
• MGI ID: MGI:3688152
• Synonyms: PD-L2^-
• Gene: Pdcd1lg2 Location: Chr19:29388319-29448561 bp, + strand Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
• Alliance: Pdcd1lg2^tm1Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113851
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A targeting vector replaced the IgV exon with the hygromycin resistance gene. (J:113851)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1lg2 Mutation: 25 strains or lines available

References

• Original: J:113851 Liang SC, et al., PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Eur J Immunol. 2006 Jan;36(1):58-64
• All: 5 reference(s)