Il5^tm1Anjm
Targeted Allele Detail

Summary

• Symbol: Il5^tm1Anjm
• Name: interleukin 5; targeted mutation 1, Andrew NJ McKenzie
• MGI ID: MGI:3688245
• Synonyms: IL-4/5/13KO
• Gene: Il5 Location: Chr11:53611621-53615930 bp, + strand Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
• Alliance: Il5^tm1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113543
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: ES cells previously targeted with the Il4/Il13^tm3Anjm mutation were targeted with a second vector, incorporating a lacZ and hygro cassette into exon 3 of the interleukin 5 locus. Resulting ES cells had disruptions of the Il4, Il5 and Il13 genes. (J:113543)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il5 Mutation: 31 strains or lines available

References

• Original: J:113543 Fallon PG, et al., IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity. 2002 Jul;17(1):7-17
• All: 3 reference(s)