Igk^tm2Rsky
Targeted Allele Detail

Summary

• Symbol: Igk^tm2Rsky
• Name: immunoglobulin kappa chain complex; targeted mutation 2, Klaus Rajewsky
• MGI ID: MGI:3688312
• Synonyms: 3-83kappaiJkappa^-, Igk^tm2Pld
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111431
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting vector was used to insert a recombined Vk3-83-Jk5 region where all endogenous Jkappa segments are deleted. (J:111431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 26 strains or lines available

References

• Original: J:111431 Pelanda R, et al., Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity. 1997 Dec;7(6):765-75
• All: 13 reference(s)