H2-DMa^tm2Liz
Targeted Allele Detail

Summary

• Symbol: H2-DMa^tm2Liz
• Name: histocompatibility 2, class II, locus DMa; targeted mutation 2, Elizabeth K Bikoff
• MGI ID: MGI:3688434
• Gene: H2-DMa Location: Chr17:34338667-34358075 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-DMa^tm2Liz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111565
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace all of exon 1 and part of exon 2 with a neomycin resistance cassette. It was determined that targeting occurred in the H2^k haplotype of the CBA ES cell parental strain. (J:111565)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	H2-DMa^tm2Liz/H2-DMa^tm2Liz	involves: C57BL/6 * C57BL/10 * C57BR * CBA

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cellular	√
decreased T cell proliferation	√
hematopoietic system	√
decreased T cell proliferation	√
immune system	√
decreased T cell proliferation	√
abnormal professional antigen presenting cell physiology	√
abnormal antigen presentation via MHC class II	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-DMa Mutation: 27 strains or lines available

References

• Original: J:111565 Koonce CH, et al., DM loss in k haplotype mice reveals isotype-specific chaperone requirements. J Immunol. 2003 Apr 1;170(7):3751-61
• All: 1 reference(s)