Apc^tm2Rak
Targeted Allele Detail

Summary

• Symbol: Apc^tm2Rak
• Name: APC, WNT signaling pathway regulator; targeted mutation 2, Raju Kucherlapati
• MGI ID: MGI:3688435
• Synonyms: Apc^580S, Apc^CKO, Apc^loxp
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm2Rak page

Stunted growth, short whiskers, sparse hair coat and abnormal tooth development in the Apc^tm2Rak/Apc^tm2Rak Tg(KRT14-cre)8Brn/0 mouse

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114152
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted through homologous recombination to flank exon 14. An adjacently inserted frt-flanked neomycin selection cassette was removed through Flp-mediated recombination, leaving a single frt site in intron 14. (J:114152)

Disease models

Expression

In Structures Affected by this Mutation:

23 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm2Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:114152 Kuraguchi M, et al., Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2(9):e146
• All: 65 reference(s)