Apc^tm2.1Rak
Targeted Allele Detail

Summary

• Symbol: Apc^tm2.1Rak
• Name: APC, WNT signaling pathway regulator; targeted mutation 2.1, Raju Kucherlapati
• MGI ID: MGI:3688437
• Synonyms: Apc^delta580
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm2.1Rak page

Multiple intestinal neoplasia in Apc^tm2.1Rak/Apc⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114152
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Apc^tm2Rak in which the loxP-flanked exon 14 sequences have been deleted by Cre-mediated recombination in the germline. A single loxP site remains in place of exon 14 and flanking intronic sequences. Loss of exon 14 is predicted to introduce a frameshift mutation and a premature stop codon, resulting in a truncated protein. (J:114152)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm2.1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:114152 Kuraguchi M, et al., Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2(9):e146
• All: 7 reference(s)