Spi1^tm2.1Dgt
Targeted Allele Detail

Summary

• Symbol: Spi1^tm2.1Dgt
• Name: Spi-1 proto-oncogene; targeted mutation 2.1, Daniel G Tenen
• MGI ID: MGI:3688440
• Synonyms: PU.1^-
• Gene: Spi1 Location: Chr2:90912750-90946104 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E3
• Alliance: Spi1^tm2.1Dgt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114150
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Spfi1^tm2Dgt in which the sequences flanked by loxP sites in introns 3 and 5 were deleted by Cre-mediated recombination in ES cells prior to the production of chimeric mice. (J:114150)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spi1 Mutation: 28 strains or lines available

References

• Original: J:114150 Iwasaki H, et al., Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005 Sep 1;106(5):1590-600
• All: 6 reference(s)