bpck
Spontaneous Allele Detail

Summary

• Symbol: bpck
• Name: bilateral polycystic kidney deletion region; bilateral polycystic kidneys
• MGI ID: MGI:3688712
• Synonyms: Tmem67^bpck
• Gene: bpck Location: unknown Genetic Position: Chr4, Syntenic

Mutation origin

• Strain of Origin: B6C3Fe a/a-tip/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Intergenic deletion
• bpck involves 12 genes/genome features (Gm25002, 4932430A15Rik, Gm22477 ...) View all
• Mutation details: This spontaneous deletion spans approximately 0.6 cM between D4Mit261 and D4Mit19, including the coding region of 6 genes, but the bilateral polycystic kidney phenotype was traced specifically to the absence of Tmem67 via BAC rescue with various length BACs. (J:144929)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any bpck Mutation: 1 strain or line available

References

• Original: J:144929 Cook SA, et al., A Mouse Model for Meckel Syndrome Type 3. J Am Soc Nephrol. 2009 Apr;20(4):753-64
• All: 4 reference(s)