Tg(CD46)2Gsv
Transgene Detail

Summary

• Symbol: Tg(CD46)2Gsv
• Name: transgene insertion 2, Frank Grosveld
• MGI ID: MGI:3688752
• Synonyms: MCP YAC, MCP-YAC line 2, MY II, Tg(CD46)2Olds, Tg(MCP)Olds2, YAC-CD46, YAC CD46 line 2
• Transgene: Tg(CD46)2Gsv Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: Tg(CD46)2Gsv page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD46)2Gsv expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD46 (4179)

  Cd46	(MGI:1203290)

• Mutation details: The transgene comprises a partially intact, approximately 420-kb yeast artificial chromosome (YAC) from the Imperial Cancer Research Fund (ICRF, London, UK), designatied AM2: 6C10, that contains the complete human CD46/MCP gene including its 5' and 3' flanking regions. The genome of transgenic mice of line MY II contains 10-12 intact copies of CD46. The expected 4.5 - 4.8-kb transcript, as well as several smaller RNAs, are expressed at high levels in all tissues examined from transgenic mice. Immunohistochemistry likewise detects patterns of expression of human CD46 protein in transgenic mouse tissues similar to those in human tissues. FACS analysis detects CD46 on transgenic spleen cells at approximately 10-fold higher levels than on human splenocytes. (J:113644)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:113644 Yannoutsos N, et al., A membrane cofactor protein transgenic mouse model for the study of discordant xenograft rejection. Genes Cells. 1996 Apr;1(4):409-19
• All: 16 reference(s)