Tg(Myh6-PRKAG2*R531G)22Dca
Transgene Detail

Summary

• Symbol: Tg(Myh6-PRKAG2*R531G)22Dca
• Name: transgene insertion 22, David Carling
• MGI ID: MGI:3688831
• Synonyms: RG-TG22
• Transgene: Tg(Myh6-PRKAG2*R531G)22Dca Location: unknown
• Alliance: Tg(Myh6-PRKAG2*R531G)22Dca page

Transgene origin

• Strain of Origin: (C57BL/10 x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-PRKAG2*R531G)22Dca expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRKAG2 (51422)

  Prkag2

  (MGI:1336153)

  Transgene codes for a protein with an arginine to glutamine mutation.

• Mutation details: This transgene consists of the human Prkag2 cDNA, with a point mutation altering arginine 531 to glycine, under the control of the cardiac-specific alpha-myosin heavy chain promoter. Western blot analysis of heart lysates confirmed that protein expression is restricted to the heart. (J:108517)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:108517 Davies JK, et al., Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome. Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1942-51
• All: 1 reference(s)