Tg(Myh6-Adra1a)A1A4Rmgr
Transgene Detail

Summary

• Symbol: Tg(Myh6-Adra1a)A1A4Rmgr
• Name: transgene insertion A1A4, Robert M Graham
• MGI ID: MGI:3689095
• Synonyms: A1A4, alpha1A-M
• Transgene: Tg(Myh6-Adra1a)A1A4Rmgr Location: unknown
• Alliance: Tg(Myh6-Adra1a)A1A4Rmgr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Adra1a)A1A4Rmgr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Adra1a (29412)

  Adra1a

  (MGI:104773)

• Mutation details: This transgene consists of the rat Adra1a gene under the control of the rat alpha-myosin heavy chain promoter, resulting in about 148-fold increase in Adra1a expression specifically in the heart. (J:108879)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:108879 Lin F, et al., Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy. Circ Res. 2001 Aug 17;89(4):343-50
• All: 3 reference(s)