Rab27a^cct
Chemically induced Allele Detail

Summary

• Symbol: Rab27a^cct
• Name: RAB27A, member RAS oncogene family; concrete
• MGI ID: MGI:3689096
• Synonyms: Rab27a^-
• Gene: Rab27a Location: Chr9:72952136-73004911 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Rab27a^cct page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, discovered by its coat color phenotype in G3 progeny of an ENU-treated mouse, has been identified as an A-to-T transversion that converts an arginine codon at amino acid position 54 to a nonsense codon (R54Ter). The RAB27A protein is not detected by immunoblot analysis of leukocyte extracts from homozygous mutant mice. (J:114299)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab27a Mutation: 146 strains or lines available

References

• Original: J:114299 Munafo DB, et al., Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem J. 2007 Mar 1;402(2):229-39
• All: 1 reference(s)