Tg(Ins2-Ccl21b)2Cys
Transgene Detail

Summary

• Symbol: Tg(Ins2-Ccl21b)2Cys
• Name: transgene insertion 2, Jason G Cyster
• MGI ID: MGI:3689181
• Synonyms: RIP-CCL21, RIP-SLC
• Transgene: Tg(Ins2-Ccl21b)2Cys Location: unknown
• Alliance: Tg(Ins2-Ccl21b)2Cys page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Ccl21b)2Cys expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ccl21b (MGI:1349182)

• Tg(Ins2-Ccl21b)2Cys expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: A full-length cDNA of murine Ccl21b was inserted into a construct containing the promoter/enhancer intron region (RIP7) of the rat insulin promoter 2. The resulting transgenic line II (2) contains 4 copies of the transgene and was used for further analyses. (J:77238)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:77238 Luther SA, et al., Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol. 2002 Jul 1;169(1):424-33
• All: 2 reference(s)