Akr1b1^tm1Tona
Targeted Allele Detail

Summary

• Symbol: Akr1b1^tm1Tona
• Name: aldo-keto reductase family 1 member B; targeted mutation 1, Toshimasa Onaya
• MGI ID: MGI:3689185
• Synonyms: Akr1b1^-
• Gene: Akr1b1 Location: Chr6:34280865-34294424 bp, - strand Genetic Position: Chr6, 14.87 cM, cytoband B1
• Alliance: Akr1b1^tm1Tona page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114187
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 1. Wester blot failed to detect protein in mutants. (J:114187)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akr1b1 Mutation: 27 strains or lines available

References

• Original: J:114187 Aida K, et al., Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis. Biochem Biophys Res Commun. 2000 Oct 22;277(2):281-6
• All: 1 reference(s)