Tnf^R8H
Spontaneous Allele Detail

Summary

• Symbol: Tnf^R8H
• Name: tumor necrosis factor; R8H
• MGI ID: MGI:3689190
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Tnf^R8H page

Mutation origin

• Strain of Origin: I/St

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: A nonsynonymous G>A substitution was found at coding cDNA nucleotide 23 (c.23G>A) in exon 1 in the I/St strain. The amino-acid substitution was positioned in the cytoplasmic region of the leader sequence in the propeptide, changing amino-acid 8 from arginine to histidine (p.R8H or p.Arg8His). (J:114302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

References

• Original: J:114302 Kahler AK, et al., A new coding mutation in the Tnf-alpha leader sequence in tuberculosis-sensitive I/St mice causes higher secretion levels of soluble TNF-alpha. Genes Immun. 2005 Oct;6(7):620-7
• All: 1 reference(s)