Slc6a3^{tm1.1(cre)Bkmn}
Targeted Allele Detail

Summary

• Symbol: Slc6a3^{tm1.1(cre)Bkmn}
• Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1.1, Cristina M Backman
• MGI ID: MGI:3689434
• Synonyms: (DAT)::Cre, DATCre, Dat^IREScre, Dat^IRESCre, DAT-IRES-Cre
• Gene: Slc6a3 Location: Chr13:73684866-73726791 bp, + strand Genetic Position: Chr13, 40.1 cM
• Alliance: Slc6a3^{tm1.1(cre)Bkmn} page

Altered dopamine neurons in the ventral midbrain of Pten^tm1Hwu/Pten^tm1Hwu Slc6a3^{tm1.1(cre)Bkmn}/Slc6a3⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114466
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Slc6a3^{tm1.1(cre)Bkmn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a3 (MGI:94862)

• Mutation details: An FRT-flanked neo was removed from the locus, leaving cre recombinase cDNA in the 3' UTR to allow bicistronic mRNA expression. (J:114466)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a3 (mouse) Summary of all recombinase alleles driven by Slc6a3. Comparative matrix view of recombinase activities Alliance mouse Slc6a3 gene page

Disease models

Expression

In Mice Carrying this Mutation:

18 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Slc6a3 Mutation: 66 strains or lines available

Notes

The targeting vector was electroporated into both R1 and C57BL/6 ES cells.

References

• Original: J:114466 Backman CM, et al., Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus. Genesis. 2006 Aug;44(8):383-90
• All: 370 reference(s)