Il5^tm3Anjm
Targeted Allele Detail

Summary

• Symbol: Il5^tm3Anjm
• Name: interleukin 5; targeted mutation 3, Andrew NJ McKenzie
• MGI ID: MGI:3689810
• Synonyms: il5^-, Il-5KO
• Gene: Il5 Location: Chr11:53611621-53615930 bp, + strand Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
• Alliance: Il5^tm3Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113543
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A replacement vector was used to insert a cassette containing: an SpeI linker with stop codons in all three reading frames, a retroviral internal ribosomal entry site (IRES) element fused to the lacZ reporter gene with a 3' polyA signal, and the hygromycin gene into a site in exon 3 of the Il5 gene. (J:113543)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il5 Mutation: 31 strains or lines available

References

• Original: J:113543 Fallon PG, et al., IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity. 2002 Jul;17(1):7-17
• All: 3 reference(s)