Del(2Hoxd1-Hoxd10)26Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd1-Hoxd10)26Ddu
• Name: deletion, Chr 2, Denis Duboule 26
• MGI ID: MGI:3689842
• Synonyms: Del(1-10), Del1-10, Del26Ddu, HoxD^Del(1-10)
• Gene: Del(2Hoxd1-Hoxd10)26Ddu Location: Chr2:74522268-74595486 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91567
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd1-Hoxd10)26Ddu involves 14 genes/genome features (Hoxd11, Hoxd10, Gm14396 ...) View all
• Mutation details: Produced by targeted meiotic recombination in a cross between engineered loxP sites in the presence of Tg(Sycp1-cre)4Min. The entire the Hoxd1 through Hoxd10 genes are deleted. Hoxd11, Hoxd12 and Hoxd13 are brought into the vicinity of a possible early limb control region. (J:91567)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd1-Hoxd10)26Ddu Mutation: 0 strains or lines available

References

• Original: J:91567 Zakany J, et al., A dual role for Hox genes in limb anterior-posterior asymmetry. Science. 2004 Jun 11;304(5677):1669-72
• All: 6 reference(s)