Abcc3^tm1Kruh
Targeted Allele Detail

Summary

• Symbol: Abcc3^tm1Kruh
• Name: ATP-binding cassette, sub-family C member 3; targeted mutation 1, Gary D Kruh
• MGI ID: MGI:3689906
• Synonyms: Mrp3^-
• Gene: Abcc3 Location: Chr11:94234121-94283823 bp, - strand Genetic Position: Chr11, 58.9 cM
• Alliance: Abcc3^tm1Kruh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114229
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6-8, including nucleotides 613-996, were replaced by a neo cassette. The substitution resulted in a frame shift. Western blot failed to detect wild-type protein in mutant mice. (J:114229)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc3 Mutation: 70 strains or lines available

References

• Original: J:114229 Belinsky MG, et al., Analysis of the in vivo functions of Mrp3. Mol Pharmacol. 2005 Jul;68(1):160-8
• All: 3 reference(s)