Mog^tm1(cre)Gkl
Targeted Allele Detail

Summary

• Symbol: Mog^tm1(cre)Gkl
• Name: myelin oligodendrocyte glycoprotein; targeted mutation 1, George Kollias
• MGI ID: MGI:3689957
• Synonyms: MOGi-cre
• Gene: Mog Location: Chr17:37321635-37334290 bp, - strand Genetic Position: Chr17, 19.16 cM, cytoband C
• Alliance: Mog^tm1(cre)Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114741
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Mog^tm1(cre)Gkl expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mog (MGI:97435)

• Mutation details: The open reading frame of the Cre recombinase gene, followed by the human growth hormone polyadenylation signal and the neomycin resistance gene, has replaced all except the 5'-most segment of the first exon, the first intron and all but the 3'-most part of the second exon of the myelin oligodendrocyte glycoprotein gene, thus targeting Cre expression to oligodendrocytes (ODCs). Western blot analysis demonstrated that wild-type MOG protein is present in heterozygous and wild-type brains at comparable levels, but is not detectable in homozygous mutant brain. (J:114741)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mog (mouse) Summary of all recombinase alleles driven by Mog. Comparative matrix view of recombinase activities Alliance mouse Mog gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mog Mutation: 58 strains or lines available

References

• Original: J:114741 Hovelmeyer N, et al., Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 1;175(9):5875-84
• All: 21 reference(s)