Tg(Myh6-Mmp2*V107G)712Ajb
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mmp2*V107G)712Ajb
• Name: transgene insertion 712, Anthony J Baker
• MGI ID: MGI:3689961
• Transgene: Tg(Myh6-Mmp2*V107G)712Ajb Location: unknown
• Alliance: Tg(Myh6-Mmp2*V107G)712Ajb page

Transgene origin

• Strain of Origin: (129/Sv x CD-1)F1

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene consists of a constitutively active rat Mmp2, with valine 107 in the prodomain mutagenized to glycine which results in the unfolding of the prodomain from the catalytic site, under the control of the cardiac specific alpha-myosin heavy chain promoter. In situ zymography confirmed that hearts exhibit increased Mmp2 activity. (J:105703)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105703 Wang GY, et al., Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Cardiovasc Res. 2006 Feb 15;69(3):688-96
• All: 2 reference(s)