Il4ra^tm2Fbb
Targeted Allele Detail

Summary

• Symbol: Il4ra^tm2Fbb
• Name: interleukin 4 receptor, alpha; targeted mutation 2, Frank Brombacher
• MGI ID: MGI:3689995
• Synonyms: IL-4Ralpha^flox
• Gene: Il4ra Location: Chr7:125151443-125178646 bp, + strand Genetic Position: Chr7, 68.94 cM
• Alliance: Il4ra^tm2Fbb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114751
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo-tk was flanked by loxP sites and inserted into intron 9 and an additional loxP site in intron 6. The neo was removed via transient cre expression, leaving exons 7-9 floxed. (J:114751)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il4ra Mutation: 46 strains or lines available

References

• Original: J:114751 Herbert DR, et al., Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity. 2004 May;20(5):623-35
• All: 67 reference(s)