Egln2^tm1Fong
Targeted Allele Detail

Summary

• Symbol: Egln2^tm1Fong
• Name: egl-9 family hypoxia-inducible factor 2; targeted mutation 1, Guo-Hua Fong
• MGI ID: MGI:3690046
• Synonyms: Phd1^-
• Gene: Egln2 Location: Chr7:26858083-26866227 bp, - strand Genetic Position: Chr7, 15.83 cM
• Alliance: Egln2^tm1Fong page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114669
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was removed via cre mediated recombination. A neo remained downstream of the deleted sequence. RT-PCR confirmed absence of wild-type transcript. (J:114669)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln2 Mutation: 18 strains or lines available

References

• Original: J:114669 Takeda K, et al., Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor {alpha} Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2. Mol Cell Biol. 2006 Nov;26(22):8336-46
• All: 10 reference(s)