Dtx2^tm1Mjb
Targeted Allele Detail

Summary

• Symbol: Dtx2^tm1Mjb
• Name: deltex 2, E3 ubiquitin ligase; targeted mutation 1, Michael J Bevan
• MGI ID: MGI:3690125
• Synonyms: Dx2-KO
• Gene: Dtx2 Location: Chr5:136023654-136061726 bp, + strand Genetic Position: Chr5, 75.64 cM
• Alliance: Dtx2^tm1Mjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114658
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1 and 2 were deleted via FLP mediated recombination. This sequence contained the ATG and encodes the first 301 amino acids of the protein and both WWE repeats. The presence of a truncated transcript was confirmed by Northern blot analysis of splenocytes. (J:114658)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dtx2 Mutation: 57 strains or lines available

References

• Original: J:114658 Lehar SM, et al., T cells develop normally in the absence of both Deltex1 and Deltex2. Mol Cell Biol. 2006 Oct;26(20):7358-71
• All: 2 reference(s)