Cib1^tm1Prse
Targeted Allele Detail

Summary

• Symbol: Cib1^tm1Prse
• Name: calcium and integrin binding 1; targeted mutation 1, Leslie V Parise
• MGI ID: MGI:3690129
• Synonyms: Cibl^-
• Gene: Cib1 Location: Chr7:79876904-79882367 bp, - strand Genetic Position: Chr7, 45.55 cM, cytoband D3
• Alliance: Cib1^tm1Prse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114645
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct replaced exons 4 and 5 with a neo cassette. These exons encode the third EF hand (calcium binding motif). Western blot confirmed the absence of protein. (J:114645)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cib1 Mutation: 24 strains or lines available

References

• Original: J:114645 Yuan W, et al., CIB1 Is Essential for Mouse Spermatogenesis. Mol Cell Biol. 2006 Nov;26(22):8507-14
• All: 9 reference(s)