Bcl2^tm1Lbox
Targeted Allele Detail

Summary

• Symbol: Bcl2^tm1Lbox
• Name: B cell leukemia/lymphoma 2; targeted mutation 1, Linda M Boxer
• MGI ID: MGI:3690216
• Synonyms: mutCRE-bcl2
• Gene: Bcl2 Location: Chr1:106465908-106642004 bp, - strand Genetic Position: Chr1, 49.76 cM
• Alliance: Bcl2^tm1Lbox page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114637
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A mutated cAMP responsive element was introduced into the promoter of Bcl2. RT-PCR detected that mRNA levels were reduced approximately 3.6-fold in B cells from the mutant mice. (J:114637)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl2 Mutation: 41 strains or lines available

References

• Original: J:114637 Xiang H, et al., Role of the Cyclic AMP Response Element in the bcl-2 Promoter in the Regulation of Endogenous Bcl-2 Expression and Apoptosis in Murine B Cells. Mol Cell Biol. 2006 Nov;26(22):8599-606
• All: 1 reference(s)