Acvr2b^tm1Spo
Targeted Allele Detail

Summary

• Symbol: Acvr2b^tm1Spo
• Name: activin receptor IIB; targeted mutation 1, S Paul Oh
• MGI ID: MGI:3690298
• Synonyms: Acvr2b^4(neo)
• Gene: Acvr2b Location: Chr9:119231184-119264061 bp, + strand Genetic Position: Chr9, 71.33 cM
• Alliance: Acvr2b^tm1Spo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114533
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a modified exon 4 such that it was fused to exon 3 as well as a floxed neo cassette that was inserted into exon 4. This mutation resulted in the expression of the shortest isoform only, as shown by Northern blot analysis. (J:114533)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr2b Mutation: 27 strains or lines available

References

• Original: J:114533 Lee YJ, et al., Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis. 2006 Oct;44(10):487-94
• All: 1 reference(s)