Myh6^tm2Ces
Targeted Allele Detail

Summary

• Symbol: Myh6^tm2Ces
• Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 2, Christine E Seidman
• MGI ID: MGI:3690300
• Synonyms: MHC^S532P
• Gene: Myh6 Location: Chr14:55179378-55204384 bp, - strand Genetic Position: Chr14, 28.01 cM
• Alliance: Myh6^tm2Ces page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• The S532P mutation was inserted into exon 16. (J:114549)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh6 Mutation: 206 strains or lines available

References

• Original: J:114549 Schmitt JP, et al., Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14525-30
• All: 3 reference(s)