Lck^tm1Dbs
Targeted Allele Detail

Summary

• Symbol: Lck^tm1Dbs
• Name: lymphocyte protein tyrosine kinase; targeted mutation 1, David B Straus
• MGI ID: MGI:3690319
• Synonyms: lckW97A
• Gene: Lck Location: Chr4:129442142-129467415 bp, - strand Genetic Position: Chr4, 63.26 cM, cytoband distal
• Alliance: Lck^tm1Dbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114660
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• The W97A mutation was inserted into exon 3. (J:114660)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lck Mutation: 95 strains or lines available

References

• Original: J:114660 Rudd ML, et al., Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development. Mol Cell Biol. 2006 Nov;26(21):7892-900
• All: 2 reference(s)