Hspa4l^tm1Imad
Targeted Allele Detail

Summary

• Symbol: Hspa4l^tm1Imad
• Name: heat shock protein 4 like; targeted mutation 1, Ibrahim M Adham
• MGI ID: MGI:3690321
• Synonyms: Hspa4l^-
• Gene: Hspa4l Location: Chr3:40699814-40750538 bp, + strand Genetic Position: Chr3, 19.51 cM
• Alliance: Hspa4l^tm1Imad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114659
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance cassette. Northern blot and RT-PCR confirmed absence of transcript in mutants. Absence of protein was confirmed by Western blot of kidney and testes. (J:114659)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa4l Mutation: 45 strains or lines available

References

• Original: J:114659 Held T, et al., Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development. Mol Cell Biol. 2006 Nov;26(21):8099-108
• All: 2 reference(s)