Ptpn11^tm1Yan
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm1Yan
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Wentian Yang
• MGI ID: MGI:3690333
• Synonyms: Ptpn11EX11_floxed, Ptpn11^tm1Ambt, SHP-2 (lox)
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm1Yan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114499
• Parent Cell Line: ESVJ-1182 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank exon 11, which encodes the catalytic motif. (J:114499)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 46 strains or lines available

References

• Original: J:114499 Fornaro M, et al., SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol. 2006 Oct 9;175(1):87-97
• All: 8 reference(s)