Retnlb^tm1Gdw
Targeted Allele Detail

Summary

• Symbol: Retnlb^tm1Gdw
• Name: resistin like beta; targeted mutation 1, Gary D Wu
• MGI ID: MGI:3690334
• Synonyms: RELMbeta^-
• Gene: Retnlb Location: Chr16:48637219-48639255 bp, + strand Genetic Position: Chr16, 30.75 cM, cytoband B5
• Alliance: Retnlb^tm1Gdw page

Retnlb^tm1Gdw/Retnlb^tm1Gdw mice are less susceptible than wild type to dextran sodium sulfate-induced colitis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114507
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced the promoter region and the first two exons. Immunoblot failed to detect protein inmutants. (J:114507)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Retnlb Mutation: 14 strains or lines available

References

• Original: J:114507 McVay LD, et al., Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. J Clin Invest. 2006 Nov 1;116(11):2914-2923
• All: 2 reference(s)